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Superoxide released into the IMS can be eliminated by a different SOD isoenzyme (Cu, Zn-SOD, or SOD1), which is found in the cytoplasm of eukaryotic cells, or scavenged by cytochrome c plus cytochrome c oxidase system (Okado-Matsumoto and Fridovich, 2001)
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Nutritional folate deficiency combined more or less with the C677T MTHFR mutation may play an important role in basal hyperhomocysteinemia, whereas vitamin B 6 deficiency and heterozygosity for a CBS defect may only contribute to abnormal increment of postmethionine-load homocysteine levels (Ubbink et al, 1996)
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