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Direct Lipolysis and Suppression of Lipogenesis# Alongside the receptor-level change, AOD-9604 has direct effects on fat-cell metabolism: it increases hormone-sensitive lipase (HSL) activity (the enzyme that liberates fatty acids from triglyceride stores) and suppresses acetyl-CoA carboxylase–driven lipogenesis (the pathway that builds new fat)
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Semaglutide mimics this hormone but lasts far longer in your body, which is why it only requires a once-weekly injection compared to the daily dosing most peptides demand
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