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The mature adipocytes secrete BMP4 that triggers preadipocyte differentiation by inducing the separation of Wnt1 inducible-signaling pathway protein 2 (WISP2) and zinc finger protein 423 (ZNF423), allowing ZNF423 to translocate into the nucleus and activate peroxisome proliferator-activated receptors (PPARΞ³) and downstream cascade including CCAAT/enhancer-binding proteins Ξ² (C/EBPΞ²), Ξ΄, and Ξ± [41, 42] ( Figure 1 )
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