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A significant pathway of c-Met signaling is the PI3K/Akt signaling axis primarily responsible for the cell survival response: the p85 subunit of PI3K can bind either directly to c-Met or indirectly through GAB1, which in turn promotes anti-apoptotic signaling through AKT (Xiao et al., 2001)
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Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
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