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While most synthesis of GSH and GSH S -conjugates occurs in the liver, this organ is very efficient at transporting these molecules out of the tissue into either bile or plasma by transport across the canalicular or sinusoidal plasma membranes, respectively
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The extracellular degradation of GSH occurs on the surface of the cells that express the enzyme γ-glutamyl transpeptidase and the dipeptidases found in the external plasma membrane (1) (Figure 5)
The assay is based on the oxidation of glutathione (GSH) to oxidized glutathione (GSSG)
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