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In addition, the treatment of CUR enhances the viability of Saos-2 cells, mitigates apoptosis, improves mitochondrial membrane function and potential, and upregulates the phosphorylation of GSK3b and protein kinase B (AKT) (83)
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Importantly, apart from inhibiting pathogen growth, iron and other components of nutritional immunity (e.g., zinc) regulate essential metabolic and inflammatory pathways in immune cells that are largely uncharacterized (365, 599)
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