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To minimally perturb the structural composition and preserve the nitro group, the handles were introduced at the 1- and 2-position as either ether or alkyl derivatives with or without an intact hydroxyl group (Fig

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These findings may provide mechanistic evidence that RANKL-induced intracellular ROS production is effectively attenuated by the loss of MT3, which upregulates NRF2, and the associated downstream antioxidant enzymes

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