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These reagents support two clinically relevant concepts: (1) Combination sensitization: FSP1 blockade can sensitize tumors to upstream ferroptosis-inducing nodes (for example, GPX4 inhibition or cystine import disruption), consistent with the idea that tumors rely on redundant antioxidant systems
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This process includes elaboration of TJs, decreased transcytosis, downregulation of leukocyte adhesion molecules and increased efflux transporter expression
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