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This delay is likely due to the time required for subsequent increases in renal IGF-1 levels, suggesting that locally produced IGF-1 may play a crucial role as a mediator of GH's renal effects.14 Of note, IGF-1 injection alone is sufficient to induce renal actions in animals with pituitary gland ablation, further supporting the importance of IGF-1 in this context.15,16 Additionally, IGF-1 administration led to an increase in GFR in healthy volunteers while simultaneously decreasing GH levels and insulin secretion
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Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler–Najjar syndrome type II
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