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Ferroptosis is a regulated, non-apoptotic form of cell death distinct from other cell death modalities Loss of GPX4 activity and subsequent accumulation of lipid hydroperoxides executes ferroptosis Diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPX4-regulated ferroptosis Inhibition of ferroptosis may represent a promising therapeutic approach for treating pathological conditions such as acute kidney injury Acknowledgement We thank Arie Zask for his critical reading of the manuscript

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While WT-engrafted tumors showed limited expansion, mtp -/- mutants supported aggressive perivascular tumor growth, particularly at neovascular branch points