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85–88 In a structure–function study, Nemeth and coworkers found that the five N-terminal residues are essential for activity
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Peroxisome proliferator‑activated receptor γ coactivator 1α and its downstream transcription factors nuclear respiratory factors 1, nuclear respiratory factors 2, and transcription factor A are key sensors of mitochondrial biogenesis, which can restore mitochondrial DNA and produce new mitochondria
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