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It is also worth being precise about who the 2005 trial actually enrolled: obese adults with a body mass index of 35 or higher
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They work through entirely different mechanisms: semaglutide is a GLP-1 receptor agonist that reduces appetite and has demonstrated 15–17% body weight loss across the large STEP trials, while AOD-9604 is a growth-hormone fragment intended to promote lipolysis but with no large-scale human trial showing significant weight loss
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