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Genome-wide cytosine methylation changes in an HD model were first observed in mouse striatal neurons expressing either pathogenic (STHdhQ111) or normal (STHdhQ7) polyQ domains
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IL-1 receptor-associated kinase 4 (IRAK4) is crucial in signaling pathways mediated by Toll-like receptor and IL-1R, which plays a key role in innate and adaptive immune responses (70, 71)
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