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7 Others 7.1 Anti inflammation can prevent the occurrence of cancer A variety of cytokines are involved in the inflammatory response, and the persistent inflammatory stimuli can damage the body tissues and disrupt the homeostasis in the body, and participate in the construction of the tumor microenvironment by altering the homeostasis in the tumor tissues, which has a significant pro-cancer effect ( Under the stimulation of chronic inflammation and intracellular infection, NF-κB, the primary response to oxidative stress, is activated and cyclooxygenase-2 (COX-2) containing its binding site is increased (Zhang et al., 2016), Naringin decreased interleukin-6 (IL-6) secretion by inhibiting the NF-κB/IL-6/STAT3 pathway, downregulated the expression of COX-2, myeloid-derived suppressor cells (MDSCs), proinflammatory mediators GM-CSF/M-CSF, and tumor necrosis factor-α (TNF-α), and increased the number of macrophages, CD4 + T and CD8 + T cells thereby slowing down the growth of colitis and colorectal adenoma cells and reducing the possibility of carcinogenesis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Berger G.K., Eisenhauer J., Vallejos A., Hoffmann B., Wesson J.A