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Inhibition of miR-378c expression promotes phenotypic transition in VSMCs, with miR-378c directly targeting the predicted transcriptional repressor sterile alpha motif domain 1 (SAMd 1) to prevent AS [75]
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When stimulated, these sensors initiate activation of complex pathways that include induction of C/EBP homologous protein (CHOP), splicing of mRNA for X-box-binding protein 1 (XBP1), called XBP1s, and phosphorylation of eukaryotic initiation factor 2α (eIF2α) [160, 161]
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