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KYNA engages G protein–coupled receptor 35 (GPR35) and AMP-activated protein kinase (AMPK) to modulate bioenergetics, thermogenesis, and lipid handling across adipose and muscle, with exercise-driven KYN aminotransferases (KATs) activity boosting KYNA output and efficiency [16,17,18]
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Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides
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