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Specifically, circPVT1 showed remarkably high expression in ESCC cells which have the resistance to 5-fluorouracil, while after knocking-down, GPX4 and SLC7A11 were significantly down-regulated, promoting ferroptosis [255]
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And yet, across them all, researchers see the same hidden thread: a silent depletion of glutathione, the body’s master antioxidant and guardian of cellular energy
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