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The iron balance dual-drive strategy (IBDS) exemplifies this concept: Deferiprone-conjugated polyamidoamine dendrimer with triphenylphosphonium mitochondria-targeting moiety (DFP-PAMAM-TPP) nanoparticles not only chelate mitochondrial iron but also promote ferritin synthesis via P5CS-mediated pathways, thereby avoiding the toxicity associated with excessive chelation while maintaining physiological iron homeostasis (125)
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Interestingly, the elevated CHAC1 levels in TP53-mutant cells might represent an adaptive response, potentially compensating for defective ferroptosis pathways or preventing harmful GSH accumulation
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