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However, studies with transfected Chinese hamster ovary cells suggest that the type-2 isozyme may actually have a neutral pH optimum in its native state, and that the acidic optimum described may actually be an artifact of cell lysis 15

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Mitochondrial function is disturbed in the absence of Nrf2 In addition to loss of cellular antioxidant capacity and modest activation of ER stress, knockout of Nrf2 diminishes mitochondrial bioenergetics and activity