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140 However, in malaria, the effects vary by disease stage: protective in mild infection but detrimental in severe forms, where IFN-γ-driven metabolic remodeling impairs mitochondrial function, triggers mtDNA release, activates STING-IRF3/7 signaling, and upregulates PD-L1, suppressing CD8⁺ T-cell activity and exacerbating parasitemia
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