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GRP78 is one of the main chaperone proteins in the ER, and under unfolded protein stress conditions, it binds to unfolded or misfolded proteins and activates downstream ER stress sensors, including inositol-requiring enzyme 1α (IRE1), protein kinase RNA-like ER kinase (PERK), and activating transcription factor 6 (ATF6), to trigger a response to unfolded proteins and the refolding process of misfolded proteins [170]
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doi: 10.1093/carcin/14.3.361
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