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It is also known that the accumulation of [Ca 2+ ] i ions induces secondary messengers (calpain and calmodulin), which may further be the causes of axonal degeneration
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While cystine deficiency also reduced p-p70S6K levels in both H1299 and A549 cells, no further reduction was observed when both cystine and methionine were depleted (Figure S3B)
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