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In the recent two decades, a plethora of studies established that elevated ROS levels generated by oxidative eustress are crucial physiological mediators of many cellular and developmental processes

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A separate study showed that TSA reduced Propionibacterium acnes-induced expression of pro-inflammatory factors (IL-1β, IL-8, and TNF-α) and activation of key proteins [TLR2, NF-κB and intercellular adhesion molecule 1 (ICAM-1)] in the TLR2/NF-κB signaling pathway in THP-1 cells, suggesting that TSA alleviates inflammation by blocking this pathway (41)

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