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The specialized nature of periosteal tissue comprising fibroblasts, osteoblasts and progenitor cells, provides optimal potential for tissue engineering due to its location and ability to differentiate 24,25
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When stimulated by ROS or induced electrophiles, Nrf2 can activate the expression of downstream II phase detoxification enzymes, including GSH-Px, superoxide dismutase, quinone oxidoreductase 1, and NQO1 (Na and Surh, 2008), and a variety of antioxidant stress proteins such as GPX4 (Zhang et al., 2018b)
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