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Under oxidative stress, DNA methyltransferases DNMT1 and DNMT3B, along with sirtuin SIRT1, relocate to CpG islands (CGIs) and form complexes with PRC2 subunits like EZH2 and EED, leading to localized DNA methylation (172)
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Prolonged, untreated B12 deficiency can cause neurological damage that does not fully reverse once corrected
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