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While this could be a strategy for the drugs to reach sites of action, the non-specific inhibition of the P-gp in non-targeted tissues could contribute to cytotoxicity

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Epigenetically, Epitalon modulates histone H1 binding and chromatin condensation in models of replicative senescence, consistent with a role in maintaining heterochromatin architecture at telomeres and pericentromeric repeats — a chromatin structure known to deteriorate with age