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As consequence of observed mitochondrial health impairment, CD38-overexpressed cells exhibited higher lactate release (Figure S11B) and glucose uptake (Figure S11C) than control cells, thus suggesting that CD38 upregulation leads to metabolic dysfunction and likely to increased glycolysis dependency in MM cells

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One instance of limbic encephalitis, one case of opsoclonus myoclonus ataxia syndrome, and three cases of acute disseminated encephalomyelitis were found in a comprehensive investigation conducted in Kerala, India [203]