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These processes are influenced by endoplasmic reticulum (ER) stress, oxidative stress, mitochondrial dysfunction, and islet inflammation (Maria et al., 2020
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p53 activation can suppress the mitochondrial tricarboxylic acid cycle and oxidative phosphorylation through inhibition of malic enzymes 1/2 or by inducing a PUMA-dependent metabolic switch (Jiang et al, 2013
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