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Example 8: 7-fluoro-2-((27?,45)-2-fluoro-4-((6-oxo-5-(trifluoromethyl)-l,6-dihydropyridazin-4- yl)amino)pentyl)-6-(5-(2-hydroxypropan-2-yl)pyrimidin-2-yl)isoquinolin-l(2H)-one Example 8 [0323] The title compound was synthesized as described in Example 1, using 2-(2- chloropyrimidin-5-yl)propan-2-ol in place of 2-iodo-5-(trifluoromethyl)pyrimidine and chiral separation was performed as described in Example 2 (stereochemistry was arbitrarily assigned)
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mTOR/MYC axis regulates O-GlcNAc transferase expression and O-GlcNAcylation in breast cancer
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