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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
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10.3389/fendo.2018.00624 111 ZhongY.LiuJ.SunD.GuoT.YaoY.XiaX.et al (2022a)
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