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Overexposure to glutamate and subsequent excess intracellular calcium influx, termed excitotoxicity, destroys neurons both in vivo and in vitro 29
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Indeed, a study has shown that treatment with ω-3 PUFAs remarkably attenuated increases in hippocampal malondialdehyde and 8-hydroxy-2′-deoxyguanosine levels as well as decreases in reduced glutathione (GSH) levels and the GSH-peroxidase activity induced by pentylenetetrazol kindling in young rat models [153]
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