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While the D1 receptor stimulates adenylyl cyclase activity, the D2 receptor inhibits it through a Gα i pathway (Missale et al., 1998

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3.1.3 Modulation of cytokines and chemokines Quantification of different cytokines and chemokines was performed with focus on those proteins involved in the inflammation (CCL2, CCL7, CCL26, CXCL10, CXCL11, ICAM-1, IL-1α, osteopontin, IFN-γ, TNF-α, IL-6, and IL-8), degradation of extracellular matrix/fibrosis (MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, TIMP-1, uPAR, uPA, serpin E1, and TGF-β1) and anti-inflammatory (IL-1ra) responses, as summarized in Table 4