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An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder
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A pilot phase I clinical trial suggests that intravenous (IV) therapy of rMETase has proven safe for high-stage cancer patients and effective in reducing methionine levels in patient serum [161]
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