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This research also validated the synergistic effect of curcumin with coenzyme Q10 in AD, further demonstrating curcumin’s antagonistic effect on oxidative stress (Kumar et al., 2023)
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Moreover, TNF-α disrupts the microstructure of lipid rafts on vascular endothelial cell membranes, interfering with the membrane localization and stable assembly of tight junction proteins such as ZO-1, thereby compromising intercellular sealing integrity
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