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Glutathione deficiency may promote cancer initiation (by failing to protect DNA from oxidative damage), while elevated glutathione in established tumors may promote cancer progression and treatment resistance (by protecting cancer cells from chemotherapy and radiation) [2][5]
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Here, we hypothesize that GGCT, a potential endogenous source of cysteine other than xCT-mediated cystine uptake, may contribute to resistance to therapies involving xCT inhibition, such as erastin
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