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No toxicity observed in animal studies at therapeutic doses Phase I/II trials for inflammatory bowel disease in the 1990s reported safety with no toxicity The human knee injection study (16 patients) reported no adverse events A preliminary 2025 study administered intravenous BPC-157 to 2 participants with no adverse effects Injection site reactions (mild redness, temporary discomfort) – relatively common Occasional mild headache during initial use – uncommon Fatigue during first few days – rarely reported Vivid dreams – occasionally mentioned Effects on existing cancers due to angiogenic properties – theoretical but unproven Unknown effects of long-term use beyond several months Interactions with medications – not systematically studied Effects during pregnancy or lactation – no data available The angiogenesis promotion by BPC-157 raises theoretical questions about use in individuals with cancer history

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Forcados et al., 2021