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similarly utilized SFE to extract target metabolites from dried blood spots (DBSs), employing methanol as a modifier to enhance the extraction process, followed by MS for detection (Matsubara et al., 2014)
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HIF-1α and its downstream effectors, such as VEGF and PDK1, alongside markers of metabolic reprogramming, including LDH and pyruvate kinase, play crucial roles in inflammation, angiogenesis, and metabolic modulation, intimately intertwined with the pathological mechanisms underlying AIDs (210)
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