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While various therapeutic interventions targeting bone marrow microenvironment, such as an IL-6 targeting monoclonal antibody siltuximab [13, 14], have been applied, however, the outcomes of these clinical trials remain largely unsatisfactory, indicating that only a partial interference with the interaction of MM and BMSC has been achieved
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Tesamorelin and bremelanotide further show that peptide-based medicines have legitimate clinical roles beyond diabetes and obesity [4,9]
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