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Participants re-randomised after 72 weeks on semaglutide or tirzepatide regained an average of 0.9 kg and approximately 5 kg respectively over 52 weeks on orforglipron
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[6] After deep intramuscular injection the lipophilic ester diffuses slowly from the oil depot, undergoes enzymatic cleavage to free testosterone and enters the systemic circulation, where roughly 98 % is reversibly bound to sex-hormone-binding globulin and albumin while the unbound fraction translocates across cell membranes to activate androgen receptors
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