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Beta-catenin-deficient mice have been reported to show elimination of Cyp2e1 and 1a2 proteins, which are associated with resistance against APAP hepatotoxicity (Sekine et al., 2006)
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In addition, a portion of synthetic agents have been used clinically to treat various diseases, such as myocardial infarction, heart failure, diabetes, hypertension, tumors, and sepsis
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