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Multi-omic resources capturing cell-type diversity across ancestries are rarer still, limiting systems-biology models that might explain why identical mutations exhibit variable penetrance in different genetic backgrounds [351]
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“This present study not only revealed the expression changes of vasoactive intestinal peptide [and its] receptors within human nucleus pulposus tissue, but also demonstrated [its] protective effects [against] degeneration,” said Jingchuan Sun, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study
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