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208 Evidence suggests that specific knockdown of astrocytes or inhibition of the gene B4galt6 (which encodes the enzyme in astrocytes that catalyzes the synthesis of lactose ceramide from the precursor molecule glucose ceramide) during the chronic/progressive phase of EAE reduces the production of chemokines and granulocyte-macrophage colony-stimulating factor, inhibiting the recruitment and activation of microglial and monocyte cells to attenuate CNS inflammation
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