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Disease-specific DAMP activation mechanisms also operate across other NDDs: For instance, α-synuclein (α-syn) oligomers in PD activate the NF-κB signaling pathway via Toll-like receptor (TLR)2/4 receptors (24), while myelin fragments in multiple sclerosis (MS)-which is primarily an autoimmune demyelinating disease-trigger inflammation through TLR4/MYD88 innate immune signal transduction adaptor (MyD88) pathways (25,26)
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