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HPXRs play an important role in macrophage function in the immune system because heme from 59 Fe–heme–HPX was efficiently incorporated into myeloperoxidase, a heme-protein in differentiated HL-60 cells (Vestal et al., 1990) and into cytochrome P-450 apo-protein (Correia et al., 2011)

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Conversely, suppression of LPCAT3 expression or function significantly attenuates ferroptosis by curtailing the formation of these oxidizable lipid species