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Although the overall number (frequency) of Tregs may be unchanged in MS patients compared to controls, studies indicate that their inhibitory function is impaired, which correlates with diminished immune control in vivo (Costantino et al., 2008)

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Feeding mice 0.5% curcumin for 14 weeks can significantly prevent age-related decreases in alpha diversity, increase bacterial richness, increase the relative abundance of Lactobacillales, and decrease the relative plenty of members of the Coriobacterales order (McFadden et al., 2015), that can utilize strong anti-inflammatory, antioxidative and antiproliferative effects (McFadden et al., 2015)