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SL significantly inhibited the intrahepatic synthesis of several disease-related pro-inflammatory cytokine mRNAs, i.e., for TNF, interferon-gamma (IFN-g), IL-4, and IL-2, intrahepatic induction of iNOS, and intrahepatic activation of NF-κB (Morishima et al., 2010
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These levels produced minimal evidence of liver toxicity by histopathological examination
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