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Thus, in cardiovascular cells, where expression of NQO1 is high and that of SOD is relatively low, induction of NQO1 was found to correlate with increased superoxide scavenging, whereas its inhibition led to a decrease in superoxide scavenging [49]
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▪ Gradual titration is essential: Opening at 2 mg weekly instead of a higher dose markedly lowers the odds of early gastrointestinal effects [4]
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