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Therefore, different from most one-target drug development strategies for AGA treatment, we think therapies to intervene in the above three main pathophysiological links simultaneously may have a better effect on promoting hair regeneration
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Post-natal growth may be disrupted by mutations that disturb the functional integrity of the cascade of GH–GHR interaction, GH signal transduction, and IGF-I production, transport, and action (Rosenfeld et al., 1994
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