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Dihexa is reported to be active at picomolar concentrations in synaptogenesis assays—approximately 10,000–10,000,000-fold more potent than BDNF (brain-derived neurotrophic factor) in some in vitro measures, though this comparison involves different assay conditions and should not be taken as a direct clinical equivalence claim
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168 An update to the literature in 2022 further showed the efficacy of heparin and lidocaine combined for relieving pain and urgency symptoms associated with IC/BPS in two studies (prospective and randomized cross-over)
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