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In addition, tumour-derived lactate and acidosis impair T cell priming by disrupting DC antigen processing and trafficking pathways, as shown by lactate-conditioned DCs with defective cross-presentation and tumour-conditioned DCs with reduced SNARE VAMP3, a regulator of endosomal trafficking required for tumour antigen cross-presentation 86,87
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PRKDC PRKDC , a gene which encodes DNA-dependent protein kinase (DNA-PK), has been shown to drive radio-resistance and chemoresistance in GBM [61, 62]
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